The Metabolism of Dimethylnitrosamine by P. N. Magee
نویسنده
چکیده
Karrer, P., Schubert, P. & Wehrli, W. (1925). Helv. chim. acta, 8, 797. Keilin, D. & Hartree, E. F. (1945). Biochem. J. 39, 289. Keilin, D. & Hartree, E. F. (1949). Nature, Lond., 164, 254. Keilin, D. & Hartree, E. F. (1955). Nature, Lond., 176, 200. Keilin, D. & Slater, E. C. (1953). Brit. med. Bull. 9, 89. Krukenberg, C. F. W. (1882). Vergleichende Physiologische Studien, series 2, part 2, p. 63. Heidelberg. MacMunn, C. A. (1883). Proc. Roy. Soc. 35, 370. MacMunn, C. A. (1885). Phil. Trans. 176, 641. MacMunn, C. A. (1886a). Phil. Trans. 177, 235. MacMunn, C. A. (1886b). Phil. Trans. 177, 267. Markham, R. (1942). Biochem. J. 36, 790. Markham, R. & Smith, J. D. (1951). Biochem. J. 49, 401. Pedersen, K. 0. (1951). Quoted by Paul, K. G. In The Enzymes, vol. 2, part I, p. 375. Ed. by Sumner, J. B. & Myrback, K. New York: Academic Press, Inc. Roche, J. & Morena, J. (1936a). C.R. Soc. Biol., Paris, 123, 1215. Roche, J. & Morena, J. (1936b). C.R. Soc. Biol., Paris, 123, 1218. Sorby, H. C. (1876). Quart. J. micr. Sci. 16, 76. Svedberg, T. (1937). Chem. Rev. 20, 81. Theorell, H. & Akesson, A. (1941). J. Amer. chem. Soc. 63, 1804.
منابع مشابه
Comparative studies on hepatic dimethylnitrosamine demethylase and some xenobiotic-metabolizing enzymes in the rat.
Dimethylnitrosamine is a potent hepatocarcinogen in a number of animal species including the rat (Magee & Barnes, 1956). Previous investigations into the hepatic metabolism of dimethylnitrosamine in vitro have shown that this compound is metabolized to formaldehyde, a process requiring NADPH and molecular oxygen (Magee & Vandekar, 1958). The requirement for these two cofactors has led to the su...
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1. Administration of a single dose of dimethylnitrosamine to rats temporarily fed on a protein-deficient diet causes a high incidence of kidney tumours. The effect of such a dose of dimethylnitrosamine (40mg/kg body wt.) on metabolism of nucleic acids and protein in rat liver and kidneys was examined during the week immediately after administration. 2. Incorporation of [(14)C]leucine and [(14)C...
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